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RABL2 promotes the outward transition zone passage of signaling proteins in cilia via ARL3.
Zhang RK, Sun WY, Liu YX, Zhang EY, Fan ZC. Zhang RK, et al. Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2302603120. doi: 10.1073/pnas.2302603120. Epub 2023 Aug 14. Proc Natl Acad Sci U S A. 2023. PMID: 37579161 Free PMC article.
Certain transmembrane and membrane-tethered signaling proteins export from cilia as BBSome cargoes via the outward BBSome transition zone (TZ) diffusion pathway, indispensable for maintaining their ciliary dynamics to enable cells to sense and transduce extra …
Certain transmembrane and membrane-tethered signaling proteins export from cilia as BBSome cargoes via the outward BBSo …
Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune ciliary signaling.
Duan S, Li H, Zhang Y, Yang S, Chen Y, Qiu B, Huang C, Wang J, Li J, Zhu X, Yan X. Duan S, et al. EMBO J. 2021 Jan 15;40(2):e105499. doi: 10.15252/embj.2020105499. Epub 2020 Nov 26. EMBO J. 2021. PMID: 33241915 Free PMC article.
Here, we show that small GTPase Rabl2 functions as a molecular switch for the outward TZ passage. Rabl2-GTP enters cilia by binding to IFT-B complex. Its GTP hydrolysis enables the outward TZ passage of the BBSome and its cargos with retrograde IFT machinery, …
Here, we show that small GTPase Rabl2 functions as a molecular switch for the outward TZ passage. Rabl2-GTP enters cilia by binding t …
Structural basis of ion uptake in copper-transporting P1B-type ATPases.
Salustros N, Grønberg C, Abeyrathna NS, Lyu P, Orädd F, Wang K, Andersson M, Meloni G, Gourdon P. Salustros N, et al. Nat Commun. 2022 Aug 31;13(1):5121. doi: 10.1038/s41467-022-32751-w. Nat Commun. 2022. PMID: 36045128 Free PMC article.
Class 1B P-type (P(1B)-) ATPases are present in all kingdoms of life, facilitating cellular export of transition metals including copper. P-type ATPases follow an alternating access mechanism, with inward-facing E1 and outward-facing E2 conformations. ...A methionin …
Class 1B P-type (P(1B)-) ATPases are present in all kingdoms of life, facilitating cellular export of transition metals including cop …
Ectocytosis prevents accumulation of ciliary cargo in C. elegans sensory neurons.
Razzauti A, Laurent P. Razzauti A, et al. Elife. 2021 Sep 17;10:e67670. doi: 10.7554/eLife.67670. Elife. 2021. PMID: 34533135 Free PMC article.
Unbalanced IFT due to cargo overexpression or mutations in the IFT machinery leads to local accumulation of ciliary proteins. Disposal of excess ciliary proteins via EVs reduces their local accumulation and exports them to the environment and/or to the glia associat …
Unbalanced IFT due to cargo overexpression or mutations in the IFT machinery leads to local accumulation of ciliary proteins. Disposa …
A positive signal prevents secretory membrane cargo from recycling between the Golgi and the ER.
Fossati M, Colombo SF, Borgese N. Fossati M, et al. EMBO J. 2014 Sep 17;33(18):2080-97. doi: 10.15252/embj.201488367. Epub 2014 Jul 25. EMBO J. 2014. PMID: 25063674 Free PMC article.
The Golgi complex and ER are dynamically connected by anterograde and retrograde trafficking pathways. To what extent and by what mechanism outward-bound cargo proteins escape retrograde trafficking has been poorly investigated. ...Our results extend the dynamic bi- …
The Golgi complex and ER are dynamically connected by anterograde and retrograde trafficking pathways. To what extent and by what mechanism …